Abstract

Environmental circumstances can modulate physiological functions and alter the action of drugs. There is now much systematic information on how the behavioral effects of drugs are modified by environmental determinants of behavior. Most drugs have selective actions on behavior in different situations, and predictions about the behavioral effects of a drug require knowledge about the conditions under which the drug is acting and the determinants of behavior in that situation. In some instances the profound effects of environmental factors in modifying the actions of drugs apply to the toxic effects of drugs; for example, it is now well known that changing the environmental circumstances can markedly enhance the lethality of amphetamine (Chance, 1946, 1967; Gunn and Gurd, 1940; Hohn and Lasagna, 1960; Weiss et al., 1961.)

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