Abstract

Objective To study the effect of distortion product otoacoustic emission (DPOAE) on guinea pigs exposed to narrow band noise of different intensity. Methods Sixty healthy male guinea pigs were randomly divided into 3 groups: the 105 dBA group, the 110 dBA group and the 115 dBA group. The duration of exposure for all the groups was 3 hours and noise spectrum was narrow - band, with a mid - frequency of 4 000Hz and band-width of 1000 Hz. Two days before and 15 minutes after noise exposure, DPOAE of guinea pigs was measured by means of Smart OAE Hearing Test System. Results With increased intensity in noise exposure, DPOAE amplitude and throughput of guinea pigs at all the distortion frequencies showed a decreased tendency. For the 105 dBA group and the 110 dBA group at the distortion frequency of 1 409 Hz, and for the 105 dBA group and the 115 dBA group at frequencies of 499 Hz,704 Hz,1 003 Hz, and 1 409 Hz, the difference in DPOAE amplitude and throughput after exposure all had statistically significance (P<0.05). Conclusions Following exposure to 4 000Hz narrow band noise, DPOAE began to change at high frequencies and heating damage extended from higher frequency to lower frequencies as noise level increased. Key words: Guinea pig; Narrow band noise; Exposure; Distortion product otoacoustic emission

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