Effects of dopamine D1 and D2 receptor agonists on environmental enrichment attenuated sucrose cue reactivity in rats.

Abstract

Acute or chronic environmental enrichment (EE) reduces sucrose cue reactivity in rats. This effect may be mediated by dopamine receptors. We examined whether dopamine D1 or D2 receptor agonism could reverse the EE effect. We also examined whether any reversal effects would vary with the incubation of sucrose craving. Following 10days (2h/day) of sucrose self-administration, rats experienced either 1 or 30days of forced abstinence and either overnight (acute) or 29day (chronic) EE. D1 (SKF 81297; 0, 0.3, or 1mg/kg) or D2 (quinpirole; 0, 0.1, or 0.3mg/kg) agonist was administered systemically immediately prior to a subsequent 2-h cue reactivity test the next day (n=9-12 per group). Dose-dependent effects were limited to the day 1 test. High doses of the agonists increased day 1 acute EE cue reactivity to levels comparable to control animals. On the day 30 test, SKF 81297 increased cue reactivity in acute EE, chronic EE, and control rats. In contrast, quinpirole resulted in similar cue reactivity for control and enriched rats, more from a reduction in responding by controls vs. a recovery of responding by EE-experienced rats. Both D1 and D2 receptors may be involved in the acute EE-mediated decrease in cue reactivity observed following 1day of forced abstinence. In contrast, at 30days of forced abstinence, D1 receptors may be critical in cue reactivity as SKF 81297 was effective at both restoring responding of enriched animals and potentiating responding of controls.