Abstract
In the intact circulation in man and dog dobutamine ( (±)-4-[2-[[3-(p-hydroxyphenyl)-1 -methylpropyl] amino]ethyl] pyrocatechol hydrochloride), a new synthetic catecholamine (Eli Lilly and Co., Indianapolis, Ind.) exerted marked positive inotropic effects (1–4). Since these effects were obtained with little change in heart rate and mean arterial pressure it has been suggested that dobutamine is potentially of clinical value in the enhancement of myocardial contractility and may have advantages over other frequently used catecholamines such as noradrenaline and isoproterenol (1–4). In view of the potential clinical value of dobutamine, and to exclude effects on the vascular system, this study was undertaken of characterize the direct effects of dobutamine on myocardial mechanics of the isolated cat papillary muscle.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Verhandlungen der Deutschen Gesellschaft fur Kreislaufforschung
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
