Abstract
A study of changes in SGOT levels was made in hypothermic Sprague-Dawley rats (rectal temperatures 23°C) which were adrenalectomized and/or treated with DMSO (41% aqueous solution injected IP) prior to hypothermia. Adrenalectomized animals exhibited slight initial increases in SGOT, but returned to control levels within 24 hours after exposure. Animals treated with DMSO alone or adrenalectomized and treated with DMSO showed significant increases in SGOT, which persisted 24 hours after exposure. Data suggests that DMSO exerts its action directly upon the cell membrane, causing permeability changes rather than indirectly by influencing the release of adrenal hormones which in turn affect membrane permeability.
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