Abstract
Uptake of radioiodide by the isolated thyroid and serum concentrations of thyroxine (T 4) and tri-iodothyronine (T 3) were determined in guinea pigs pretreated with ethacrynic acid (20 mg/kg), furosemide (40 mg/kg) or hydrochlorothiazide (40 mg/kg). It was found that both ethacrynic acid and furosemide suppressed the 131I − uptake by the isolated thyroid tissues. In addition, thyroid weight and serum T 3 concentration were lower in ethacrynic acid-treated animals. It seems that some diuretics, particularly ethacrynic acid, depressed the function of thyroidal follicular cells.
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