Abstract
Comparative examinations of dissolution testers were made, using seven iron agents of different manufactures, including quick- and slow-releasing preparations. The dissolution testers investigated were rotating basket method of U.S.P. XVIII or N.F. XIII and the solubility simulator method which was devised recently by Sartorius Membrane-Filter Company. Despite little difference in the dissolution patterns obtained by these two methods in the case of quick-releasing preparations, apparent and serious differences were revealed in the case of slow-releasing iron preparations. The results obtained by the solubility simulator method had a tendency of accelerating the dissolution of sustained release preparations. The reason for these differences was considered to be disintegration or scratching of the film surface of the preparations by glass balls (approximately by 247 balls) in the dissolution chamber of the solubility simulator during the course of testing.
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Schedule a callMore From: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
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