Abstract
Comparative dissolution kinetics were studied for ropinirole formulations using two media with pH 4.0: phosphate buffered solution (200 rpm) and citrate buffer (100 rpm). The study results showed that the components of the dissolution medium affected release profiles and the stability of the active ingredient even at identical pH. The optimum dissolution medium was citrate buffer solution, which provided the best release of active ingredient, with retention of the structure of the active substance.
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