Abstract
It is well known that anticholinergic agents such as atropine and scopolamine are effective as anti-motion sickness drugs, however, the mechanism of action in the vestibular system is inadequately understood. It has been demonstrated by several investigators (1–5) that neurons in the vestibular nucleus are excited by local application of acetylcholine. Gerebtzoff (6) has sfibwn a histochemical localization of cholinesterase in the vestibular nucleus of cats. Contents of the enzyme were relatively high in the superior and lateral parts of the nucleus, but low in the medial and inferior parts. According to the hypothesis of Wood and Graybiel (7), motion sickness occurred when activation of the central cholinergic system disturbed the balance of vestibular reactions, and protection would be achieved by utilizing anticholinergic drugs.
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