Abstract
Dipeptidyl peptidase 4 (DPP-4) inhibitors are new anti-diabetic drugs; such as alogliptin; linagliptin; saxagliptin; sitagliptin and vildagliptin; can reduce blood glucose mainly by inhibit glucagon release through the enhancement of glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP) [1]. DPP-4 inhibitors are also proposed have beneficial Cardioprotective effects [2]. Cardiovascular disease (CVD) is a major cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM) [3,4]. Some research shows that chronic treatment with DDP-4 inhibitors may have cardioprotective effects in diabetes patients presenting with acute coronary syndrome [5].
Highlights
Dipeptidyl peptidase 4 (DPP-4) inhibitors are new anti-diabetic drugs; such as alogliptin; linagliptin; saxagliptin; sitagliptin and vildagliptin; can reduce blood glucose mainly by inhibit glucagon release through the enhancement of glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP) [1]
Some research shows that chronic treatment with DDP-4 inhibitors may have cardioprotective effects in diabetes patients presenting with acute coronary syndrome [5]
Evidence from preclinical studies suggests that dipeptidyl peptidase-4 (DPP-4) inhibitors could have beneficial effects on atherosclerosis in both GLP-1-dependentand -independent manners [9]
Summary
Dipeptidyl peptidase 4 (DPP-4) inhibitors are new anti-diabetic drugs; such as alogliptin; linagliptin; saxagliptin; sitagliptin and vildagliptin; can reduce blood glucose mainly by inhibit glucagon release through the enhancement of glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP) [1]. DPP-4 inhibitors are proposed have beneficial Cardioprotective effects [2]. Some research shows that chronic treatment with DDP-4 inhibitors may have cardioprotective effects in diabetes patients presenting with acute coronary syndrome [5]. Carotid intima-media thickness (IMT) is a marker for atherosclerosis [8]. Evidence from preclinical studies suggests that DPP-4 inhibitors could have beneficial effects on atherosclerosis in both GLP-1-dependentand -independent manners [9]. The aim of this study was to determine the effect of DPP-4 inhibitors treatment on Carotid Intima-Media Thickness in diabetic patients; by means of a systematic review and a metaanalysis. Recent studies suggested that dipeptidyl peptidase-4 (DPP-4) inhibitors benefit to atherosclerosis-related cardiovascular diseases, but evidence was inconclusive. We aimed to determine the effects of dipeptidyl peptidase-4 inhibitors on Carotid Intima-Media Thickness in type 2 diabetes patients
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