Abstract
Developmental exposure to organophosphate insecticide is well known to induce neurobehavioral impairments, at late period. The present study aims to investigate the effects of subchronic exposure to Dimethoate, on locomotors skills and anxiety like behavior among wistar rat. Two groups of female’s rats are used. The intoxicated group receives daily, during five weeks, by intragastric gavage, a dose of Dimethoate dissolved in corn oil (100 mg/kg body weight). The control group receives only the corn oil. Spontaneous locomotors activity is evaluated using the Open Field test (OF) and anxiety-like behavior is measured using Elevated Plus-Maze (EPM). Dimethoate induced significant impairment of spontaneous locomotors activities, which is reflected by high decrease of number of squares crossed (SC) in OF. Females exposed to Dimethoate develop further anxiety-like response, expressed by significant reductions of the time spent in open arm of Elevated Plus-Maze.
Highlights
Females exposed to Dimethoate develop further anxiety-like response, expressed by significant reductions of the time spent in open arm of Elevated Plus-Maze
The frequencies of line crossing with the four paws, the time spent in center of open-field and number of rearing in exploratory activity, were recorded by video camera positioned above the Open Field test (OF)
This was demonstrated by the work of Acker [40], which reported that Malathion inhibited Na + K + ATPase activity in the cerebral cortex of adult rats, an event that is implicated in the neurotoxicity induced by this compound
Summary
Their general persistence in crops products and in environment is considered as hazardous for the public health [1] [2] [3]. The acute neurotoxic mechanism of action of Dimethoate is typically cholinergique. It involves an inhibition of the Acetylcholinesterase (AChE) of the neuronal tissue through its active metabolic shape, the Omethoate which turns out to be 10 times as toxic as the Dimethoate (WHO, on 2003). The acute and sub chronic physical effects of Dimethoate exposure are well documented [11] [12], there are a limited number of studies describing the neurobehavioral deficits caused by this OP. The current study aims to investigate the effects of exposure to sub toxic doses of Dimethoate, on locomotors skills and anxiety like-behavior in Wistar rats
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