Abstract
Dihydropyridines are reported to have a stimulatory effect on vascular smooth muscle Na, K-ATPase activity in vitro. We studied the effects of the dihydropyridine calcium antagonists nimodipine, nitrendipine, nitoldipine, niludipine, nifedipine and felodipine (10 −5 M) on purified Na,K-ATPase isolated from rabbit kidney outer medulla. We were unable to detect an effect of the drugs on the enzyme activity, either under optimal or suboptimal substrate conditions. Likewise, NaK-ATPase activity, partly inhibited by the addition of ouabain (10 −6 M), Ca 2+ (10 −3 M) or arachidonic acid (4×10 −5 M), was not influenced by the dihydropyridines. The absence of a stimulatory effect of dihydropyridines on renal Na,K-ATPase is in agreement with the known diuretic and natriuretic effects of the drugs in normotensive and hypertensive men.
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