Abstract
The aim of the current investigation has been to evaluate the toxic effects of Diflubenzuron (DFB) insecticide on domestic rabbits. In this study, we aimed to evaluate the toxicity of DFB on some reproductive parameters in male Oryctolagus cuniculus rabbits. In animals (6 to 7 months and 1700 ± 170 g) the insecticide was used on three different doses:250,500,750 mg/kg. The insecticide was daily administrated for four weeks of experimental periods. Results showed the following effects as compared with the control group: a-decrease in reproductive indicators (concentration, motility, speed, and vitality of spermatozoa) and in serum testosterone concentration. Histological examination showed pathological alterations such as a remarkable reduction in spermatozoa concentration and cellular malformation within seminiferous tubules and epithelial cells especially in groups treated by the highest dose of Diflubenzuron, data demonstrated that DFB caused an effect on reproductive function in adult male rabbits.
Highlights
A Pesticide is defined as any substance or combination of substances used to prevent or eradicate unwanted including vectors of diseases in human beings and animals, weeds, fungi, or animals in order to enhance food production and help production processing, storage, transport, or marketing of the food and agricultural commodities (Abdollahiet al,.2004 .celementiet al,.2008 shadnia et al,2005,Sifakis et al,.2011) but the use of the sesubstances for a long term caused toxicity on environment (Pogribny Rusyn, 2013) because pesticide residues are found in the food chain, soil and water supplies (Roma et al,.2012)
Maturation,and transfer of sperms, the existence of appropriate levels of sex hormone is essential,a change in the level of test .L,H, and FSH can distrupt the process of sperm product (Frang et al,.2010) some studieswereconfirmed our work by (Yousef et al,.2003) who reported impairments of cypermethrin on mal rat reproduction system similar effects were observed by (Issamet al,.2011) after subcutaneous PM treatment
Semen quality refers to some characteristics measured in freshejaculate, the volume of the semen, sperm concentration,percentage of mobile sperms, and sperms with normal.In this work, we can explainthe very high decrease of sperms in thegroup treated with DFB compared to the control group
Summary
A Pesticide is defined as any substance or combination of substances used to prevent or eradicate unwanted including vectors of diseases in human beings and animals, weeds, fungi, or animals in order to enhance food production and help production processing, storage, transport, or marketing of the food and agricultural commodities (Abdollahiet al,.2004 .celementiet al,.2008 shadnia et al,2005,Sifakis et al,.2011) but the use of the sesubstances for a long term caused toxicity on environment (Pogribny Rusyn, 2013) because pesticide residues are found in the food chain, soil and water supplies (Roma et al,.2012). Pesticides exposure has increased the concentration of their potential hazard to the health including acute and chronic poisoning (Mostafalou and Adolhali2013 a,b) it has adverse effects on central nervous, endocrine and reproductive systems (Saadiand Abdolahi2012a,b) heart damage (Vadhana et al,.2011). Some pesticides are agents disrupting the endocrine glands leading to change in the normal level of reproductive hormone (Souheila et al,.2011, Tabb and Blumberg,2006). Other negative effects of pesticides in male infertility include a disorder in the normal differentiation of chromosomes during meiosis by causing number anumalies in sperm chromosomes (Wasim et al,.2009). Pesticides infiltrate the blood circulation and directly head to the production on inferlit sperms by damaging and destroying the cells of the testes tissue or as mutagenic substances in Cells (Larsen et al,.1998).
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