Abstract
The 24-hr percentage of /sup 35/S incorporation into platelets of mice in rebound thrombocytosis was compared after single or multiple sc and ip injections of a thrombopoietin (TSF)-rich preparation. TSF administered sc or ip resulted in almost identical percentage of /sup 35/S incorporation values. Various doses of TSF injected sc two times on Day 5 after RAMPS and two times again on Day 6 gave a linear dose-response curve. Also, this injection schedule gave the greatest response to the same total dose of TSF when compared to other injection schedules. Single injections of TSF did not give as great a response as did multiple injections using the same total dose. Results of this work indicate that for maximum percentage of /sup 35/S incorporation values, TSF-rich materials should be administered in multiple injections to mice, either sc or ip, over a period of approximately 2 days.
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Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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