Effects of different intensity aerobic exercise on intestinal flora and gastrointestinal hormones in type 2 diabetic rats

Abstract

To examine the impact and mechanisms of the aerobics exercise on gut flora and gastrointestinal hormones in type 2 diabetes rats. Methods Adult male SD rats aged 8 weeks were divided into 5 groups at random (n= 10): a peaceful comparison group (N), a diabetic comparison group (D), a diabetic low-intensity exercise group (LD), a diabetic middle-intensity exercise group (MD), and a diabetes highintensity exercise group. (HD). The rat groups LD, MD, and HD performed aerobic exercise five times per week for a total of 6 weeks and compared general condition, blood glucose, blood lipids, insulin, leptin, gastrin (GAS) and motilin ( MOT), gastrointestinal motility, and intestinal flora. Results The levels of insulin, leptin, total cholesterol, triglycerides, E. coli, LDL-cholesterol, LDL-cholesterol, insulin, and gastric residual rate were significantly different from group N. Conclusion: Type 2 diabetic rats have gut flora imbalance and gastrointestinal hormone changes. Aerobic exercise with different intensity can alleviate gastrointestinal hormone imbalance and intestinal flora imbalance in type 2 diabetes rats, and the impact of moderate intensity exercise is the strongest.