Abstract
This study evaluated the effects of different forms of chromium supplements on serum glucose, insulin and lipid concentrations in rats. Sprague-Dawley male rats were randomly assigned to one of three dietary groups and fed AIN-76 semi-purified basal diets supplemented with 300 ppb Cr from Cr methionine (CrMet) and Cr chloride (CrCl₃) or without Cr (control). By the end of the 4^(th) week, all rats were decapitated, blood collected, and serum glucose, insulin and lipid concentrations were determined. The CrMet and CrCl₃ supplementation did not affect weight gain and feed efficiency ratio. However, feed intake was significantly higher in CrMet groups than control (p＜0.05). CrMet-supplemented rats had markedly increased insulin levels (p＜0.05) compared with controls. Serum lipids were not significantly different between the control and the CrMet groups. CrCl₃ supplementation decreased total cholesterol and triglyceride, but the decreases were only significant for the control group. CrCl₃ supplementation was associated with significant decreases in total cholesterol compared with CrMet supplementation. These results indicate that CrMet supplementation is effective for increasing serum insulin, and CrCl₃ may improve lipid concentrations, because we observed decreased serum total cholesterol and an improved total cholesterol/HDL-cholesterol ratio (THR).
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