Effects of different doses of heparin - encapsulated solution on coagulation mechanism in elderly patients with cardiac surgery

Abstract

Objective: To investigate the effect of different doses of heparin-encapsulated liquid on the coagulation mechanism of elderly patients with cardiac surgery using superficial venous indwelling needle, and to select safe and effective dose of heparin-sealing fluid for elderly patients without increasing cardiac load. Methods: Select the use of superficial venous catheter in the heart of the coagulation function of normal elderly patients with 100 cases were randomly divided into two groups, respectively using heparin saline solution 5mL (containing heparin 62.5U / mL), 3mL (containing heparin 50.0U / mL) for indwelling needle tube, carry out before catheterization and disable heparin tube solution 24h prothrombin time (PTT), activated partial thromboplastin time (APTT), fibrinogen (Fg), and observe for any signs of bleeding (such as skin, mucous membrane with or without bleeding), while recording the retention time of indwelling needle. Results: There were no significant differences in PT, APTT and Fg between the two different doses of heparin tube (P> 0.05). There was no significant difference in the number of days between the two different doses of heparin sealed fluid and the retention time of indwelling needle (P <0.05). Conclusion: It is safe and reliable to use the above different dose of heparin sealed fluid in elderly patients with normal cardiac coagulation mechanism. Indwelling needle sealing with a small dose of low concentration of heparin sodium dilution is better, both to reduce the burden on the heart, save time, and will not affect the coagulation function.