Effects of different degrees of coagulation disorders after surgery on short-term prognosis in patients undergoing cardiac surgery with cardiopulmonary bypass

Abstract

Objective To evaluate the effects of different degrees of coagulation disorders after surgery on short-term prognosis in patients undergoing cardiac surgery with cardiopulmonary bypass(CPB). Methods A total of 410 patients of both sexes, aged 18-79 yr, with body mass index of 16-28 kg/m2, of American Society of Anesthesiologists physical status Ⅲ or Ⅳ, scheduled for elective cardiac surgery with CPB, were enrolled in the study.After induction of general anesthesia, the patients were tracheally intubated and mechanically ventilated.Combined intravenous-inhalational anesthesia was used.The patients were divided into 3 groups according to the coagulation function at 6 h after surgery: normal function group(n=55), mild disorder group(n=237)and severe disorder group(n=118). Postoperative mechanical ventilation time, duration of intensive care unit stay, length of hospitalization and complications during hospitalization were recorded. Results Compared with normal function group, the length of hospitalization was significantly prolonged, and the rate of delayed discharge from hospital was increased in mild disorder group, and the ventilation time, duration of intensive care unit stay and length of hospitalization were significantly prolonged, the rate of delayed extubation, rate of prolonged intensive care unit stay and rate of delayed discharge from hospital were increased, and the hepatic and nephritic insufficiency and incidence of re-thoracotomy for bleeding were increased in severe disorder group(P 0.05). Conclusion For the patients undergoing cardiac surgery with CPB, postoperative mild coagulation disorders exert no effect on short-term prognosis, however, postoperative severe coagulation disorders produce poor prognosis, and correction of severe coagulation disorders should be taken into account. Key words: Blood coagulation disorders; Cardiopulmonary bypass; Cardiac surgical procedures; Prognosis