Abstract
To study the influence of different concentrations of TGF-β_1 on the number and transdifferentiation of epithelial cells in endometrial tissue. 40 cases of normal endometrial tissue obtained by surgery in our hospital were collected, and epithelial cells were separated. According to the random number table method, cells were assigned into normal control groups (only with culture solution) and experimental groups (TGF-β1 was added on the basis of the above), the experimental group is further assigned into three groups, that is, low-dose (3 ng/ml), medium-dose (6 ng/ml) and high-dose (9 ng/ml) TGF-β_1 group followed by analysis of cell numbers, FN, α-SMA and Col-I level. FN secretion in normal control group was (0.469±0.010) ng/L, and ColI secretion was (0.532±0.033) ng/L. There was a difference between FN values and Col-I values in each experimental group (P < 0.01); α-SMA and other data in the experimental group had opposite effects compared with control group with significant differences for different concentrations of TGF-β_1. As concentration gradually increased, E-cadherin level in cytoplasm will gradually decrease. On the contrary, α-SMA level in cytoplasm will gradually increase (P < 0.05) (F = 145.125, 179.511, P < 0.01). TGF-β_1 stimulates the increase in of number of epithelial cells in endometrial tissue and induces them to transform into myofibroblasts dose dependently
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