Effects of Different Components of Mao Dongqing's Total Flavonoids and Total Saponins on Brain Tissue of TIA Model Mice

Abstract

Objective: To investigate the effects of total flavonoids and total saponins in different ratio of Mao Dongqing effect of components on brain tissue of TIA mice. Methods: mice were intravenously injected with 0.11 mol/L tert butyl hydroperoxide (7.5ml/kg) after 10min 0.45L, sealed in a jar, and the mice after 15min of hypoxia Administration for 3 days were removed. First TIA mice induced by continuous intragastric administration for 3 days continuously. 1 cycles per period for 1 times by TIA, a total of 3 cycles. On the second day third times and scoring after induced by TIA after administration of 1H, the mice were killed immediately, the separation of the brain, the brain in the half of 10% formalin solution fixed, do the hippocampus pathological section; the other half of the brain was made 10% brain homogenate, for determination of the content of MDA and activity of SOD. Results: the total flavonoids and total saponins in different proportions of Maodongqing components can significantly reduce the content of MDA in brain tissue of mice model and brain tissue increased in mice SOD level can significantly improve the pathological changes of the brain. Conclusion: hairy holly root total flavone and total saponins in different ratio of group points can be significantly reduced TIA model to improve the scavenging free radicals have a good effect, on transient cerebral ischemia attack better control effect.