Effects of different amounts and types of dietary fatty acids on body weight, fat accumulation and lipid metabolism in hamsters

Abstract

The study explored the effects of different amounts of dietary fatty acids on body weight, fat accumulation and lipid metabolism in hamsters. We conducted 12 wk intervention with sixty male golden Syrian hamsters were randomly divided into six groups. Three of the groups fed with experimental diets containing 5%, 15% and 20% (w/w) fat of soybean oil (S5, S15 and S20). And the other fed with experimental mix oil (M5, M15 and M20). The experimental mix oil consist of 60% monounsaturated fatty acids (MUFAs) and polyunsaturated‐to‐saturated fatty acid (P/S) ratio 5 mix by soybean oil and canola oil. The result showed that the S20 group's weight and weight gain were significantly greater than the other five groups. When the total fat consumption increased, the S group's body weight, weight gain and adipose tissue weight will significantly increase, but they were no significant difference in the M groups. When S20 compared with M20 group, S20 had significantly higher leptin, insulin concentration and promote triglyceride accumulation enzyme lipoprotein lipase (LPL), but lipolysis enzyme acetyl‐CoA oxidase (ACO) and carnitine palmitoyltransferase‐1 (CPT‐1) was significantly lower. Therefore, the study showed that special proportion of experimental mix oil with high fat can prevent body weight gain and body fat accumulation by lowering insulin concentration and increased hepatic lipolytic enzyme activities.Grant Funding Source: National Science Council