Abstract
The present study was undertaken to explore in 20 male surgical patients the effects of ether anaesthesia alone on the carbohydrate and fat metabolism by determining plasma growth hormone, insulin, blood glucose, free fatty acids (ffa), and cortisol, and to compare them with the effects of anaesthesia associated with operation. Determination of plasma growth hormone (hgh), insulin, cortisol, free fatty acids (ffa), and blood glucose were made simultaneously before induction of diethyl ether anaesthesia, after induction of anaesthesia for 45 minutes, during, and after conclusion of the operation. Plasmahgh concentrations during ether anaesthesia showed a significant elevation, rising remarkably 1 hour after the start of the operation. A relative decrease in plasma insulin level and increases in blood glucose were noted during ether anaesthesia and operation. But no demonstrable variation of the bloodffa level was found during anaesthesia alone or during operation. Plasma cortisol levels significantly increased stepwise during anaesthesia and operation. Our observations would suggest that the increased blood level of growth hormone, lowered plasma insulin concentration, and elevated blood cortisol play a part in the increase of blood glucose during ether anaesthesia and operation in man.
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