Effects of dietary turmeric (Curcuma longa) on innate and acquired immune responses in broiler chicken

Abstract

One of the most desired treatments to combat stress and inflammation with minimal adverse effects in large bird populations is food additives. This study investigated the effects of dietary turmeric (Curcuma longa) on the level of serum amyloid A (SAA) as an indicator for acute phase response and antibody titer to Newcastle vaccine as an indicator for humoral immune response. A total of 300 Ross broiler chickens were assigned to five dietary groups. Two treatments received basal diets supplemented with different amount of turmeric (250 and 500 mg/kg). One group received aspirin (ASA; 250 mg/L) and one group aspirin-vitamin C (ASA; 250 mg/L + Ascorbic acid; 20 mg/L) in drinking water. There was one control group that received no feeding additives. The levels of SAA and humoral antibody response to Newcastle vaccine were measured during the entire production period. Turmeric administration significantly decreased the serum SAA concentrations after 2 weeks of treatment and later. It also significantly reduced SAA elevation due to the vaccinations on day 17 but not on day 28. After the second vaccination (d 19) ELISA titer in all treatment groups was higher than control group. Significant effect of dietary turmeric on body weight was also found at week 3 and later ages. Administration of 250 mg turmeric per kg diet is recommended for broiler chickens. It is concluded that turmeric is beneficial to minimize inflammatory effects of vaccination in commercial broiler chickens. Turmeric prevents and reduces stress and negative effects of inflammation and stimulates growth performance of broiler chickens.