Abstract
This study aimed to investigate the protective effects of dietary glutamate and aspartate supplementations on diquat-induced oxidative stress in piglets. Diquat injection significantly reduced growth performance, including body weight, average daily weight gain, and feed intake (P<0.05). Meanwhile, diquat administration induced oxidative stress evidenced by the decreased serum nitric oxide (NO) and elevated malondialdeyhde (MDA) concentration (P<0.05). Furthermore, diquat-induced oxidative stress disrupted intestinal absorption system and decreased serum threonine, serine, and glycine levels. Dietary supplementation with glutamate improved final body weight, antioxidant system, and expressions of amino acids transporters and enhanced serum glutamate concentration compared with diquat group (P<0.05). While aspartate failed to alleviate diquat-induced oxidative stress, growth depression, and dysfunction of nutrients absorption except for liver relative weight. In conclusion, dietary supplementation with glutamate confers beneficial effects on diquat-induced oxidative stress in piglets, while aspartate exhibits little effects.
Highlights
Oxidative stress can be induced by various factors during the animal growth and development, including physical, social, and pathological environments [1,2,3]
We found that pathological factors such as mold-contaminated feed, porcine circovirus type 2 infection, and dextran sulfate sodium-induced colitis exhibit an inhibitory effect on activities of antioxidant enzymes and induce oxidative stress in pigs and mice [3,4,5]
Supplementation with glutamate restored the inhibitory effect of body weight caused by diquat (P < 0.05)
Summary
Oxidative stress can be induced by various factors during the animal growth and development, including physical (weaning, housing, transport, and novel handling), social (relocation with unfamiliar penmates), and pathological environments [1,2,3]. We found that pathological factors such as mold-contaminated feed, porcine circovirus type 2 infection, and dextran sulfate sodium-induced colitis exhibit an inhibitory effect on activities of antioxidant enzymes and induce oxidative stress in pigs and mice [3,4,5]. Our latest studies revealed that birth and PLOS ONE | DOI:10.1371/journal.pone.0122893. Our latest studies revealed that birth and PLOS ONE | DOI:10.1371/journal.pone.0122893 April 15, 2015
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