Abstract
Sprague-Dawley rats were fed hypercholesterolemic regimens with either soy protein (S) or casein (HC) as the protein source. Lipid, lipoprotein composition as well as lecithin cholesterol acyltransferase activity (LCAT) were measured in plasma. Liver lipid levels and enzyme activities, cholesterol 7α-hydroxylase and acylCoA cholesterol acyltransferase (ACAT), were also determined. Plasma cholesterol levels were significantly reduced with the S as compared with the HC diet, but LCAT activity was not modified. Cholesterol 7α-hydroxylase, which increases in animals fed hypercholesterolemic diets as compared to controls, was unaffected when S was substituted for casein. In contrast, higher cholesterol ester levels and an elevated ACAT activity were observed in the liver of rats on the soybean diet. Substitution of casein with soy protein reduced cholesterol levels in all lipoprotein fractions but no changes were observed in apoproteins.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
