Abstract
Polychlorinated biphenyls (PCBs) induce CYP1A, modulate immune responses, and may have endocrine disruption properties. Many coastal ecosystems and their tributaries contaminated with PCBs also receive sewage out-fall effluents containing detergents such as nonyl-phenol (NP). Because NP has estrogenic properties and modulates P4501A activity, and because estrogen modulates immune function in a variety of vertebrates, studies to investigate interactions of PCBs and NP are needed. Channel catfish ( Ictalurus punctatus) (25–30 g) were fed seven different diets containing 10 ppm Aroclor 1254 (PCB), 10 ppm NP, Wppm PCB + 10 ppm NP, 100 ppm PCB + 10 ppm NP, 10 ppm PCB + 100 ppm NP, 100 ppm of each, or carrier. After 7 and 21 days of treatment peripheral blood hematocrits, total serum protein and immunoglobulin, antigen-specific antibody, anterior kidney phagocyte oxidative burst, and gut/liver cytochrome P4501A protein/EROD, were evaluated. Phagocyte function was enhanced by low NP on day 7 and low PCB + high NP on day 21. Gut and liver P4501A protein/EROD were greatly induced by combinations of high PCB + high and low NP. Treatments did not effect hematocrits, serum protein or total immunoglobulin on either day or antibody titers on day 21 against formalin-killed Edwardsiella ictualuri (day 14 post sensitization).
Published Version
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