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Abstract
Heavy industrial pollution and/or passive smoking negatively affect the overall immune health of a population. We used a model of children with chronic respiratory problems and evaluated the effects of short term supplementation of their diet with nucleotides. We measured the level of sIgA, eNO levels and total physical activity. We found positive effects of oral supplementation with commercially available nucleotides. Our data demonstrate strong improvements in physical activity, strong decrease of eNO levels and maintaining of the levels of sIgA. We conclude that supplementation with nucleotides offers an easy way to improve health conditions in children.
Highlights
A long-term focus of our laboratory is the research of how the environmental conditions affect the health of population
We report our results in supplementation of food with high content of dietary Nucleotides (dNT) in children from a heavily contaminated environment
We found a significant increase in 6 Min Walk Test (6MWT) levels in both the female and male groupsfrom 448 to 470 in males, from 403 to 427 in females
Summary
A long-term focus of our laboratory is the research of how the environmental conditions affect the health of population. We are focused most of all on children with chronic respiratory problems caused by living in industrial regions of northern Bohemia and northern Moravia where the extremely high concentration of environmental contamination helped to gain the term Black Spot of Europe. The fact that this region is populated mostly by people with lower education, often disregarding the basic rules of healthy living, with a prevalence of smoking reaching 60-90%, makes the health situation even worse.
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