Abstract
The objective of this study was to evaluate the effects of dietary nucleotide supplementation on growth performance, serum immunoglobulin G (IgG) and uric acid levels, immune-related organs, and intestinal morphometric parameters of broiler chickens under pre- and post-inflammatory challenge with lipopolysaccharide (LPS). Ninety-six seven-day-old male broiler chicks were randomized in a 2×2 factorial design composed of two dietary types (supplemented with 0 and 0.3 g of purified nucleotides/kg of feed) and two inflammatory conditions (with and without LPS administration) [...]
Highlights
Nucleotides are the fundamental molecules of nucleic acids and play crucial roles in storage and transfer of genetic information, cell division, and protein synthesis
The objective of this study was to evaluate the effects of dietary nucleotide supplementation on growth performance, serum immunoglobulin G (IgG) and uric acid levels, immune-related organs, and intestinal morphometric parameters of broiler chickens under pre- and post-inflammatory challenge with lipopolysaccharide (LPS)
Birds supplemented with nucleotides showed increased (P
Summary
Nucleotides are the fundamental molecules of nucleic acids and play crucial roles in storage and transfer of genetic information, cell division, and protein synthesis. The endogenous de novo synthesis of nucleotides and salvage pathways are considered sufficient to fulfill cellular requirements (Sanchez-Pozo and Gil, 2002). These nutrients may become occasionally essential under certain conditions, such as rapid growth or immunological challenge (Leung et al, 2019a). Exogenous supplementation of these compounds may be essential to support growth and maintain functions. Effects of dietary nucleotide supplementation on growth performance and physiology of broiler chickens...
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