Abstract
Weanling rats were fed diets containing additional levels of 0, 100, 500 and 1000 ppm nickel acetate. High levels of nickel depressed growth, packed cell volume, hemoglobin, and tissue cytochrome oxidase and alkaline phosphatase activities, but had no effect on plasma ceruloplasmin concentrations. The presence of dietary nickel resulted in its accumulation in both plasma and red blood cells. This had no influence on the concentration of copper, but increased the iron and zinc concentrations in these blood components. Nickel accumulated in the heart, liver, testes, and kidney (kidney to the greatest extent). Nickel had no effect on copper content and only a slight effect on zinc content, but significantly increased the iron concentrations of these tissues. Nickel accumulated in the soluble fraction of the liver, and in the soluble fraction, and nuclei and debris of the kidney. This caused an accumulation of iron in all the cellular fractions of these two tissues.
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