Effects of dietary fructose, glucose, fibers and hypolipidemic drugs on serum and liver lipids in rats.

Abstract

To investigate the effects of dietary glucose and fructose on serum lipids, rats of four strains (Donryu, Sprague-Dawley, Fischer and Wistar) were fed a diet containing either glucose or fructose. Fructose feeding to all rats weighing about 140g of the four strains resulted in significant increases in serum cholesterol and triglyceride.Of the Donryu rats with initial body weights of 65 g, 179g and 463 g, serum cholesterol increased in those weighing 179g when fed a fructose diet. Whereas, fructose feeding resulted in significant increases in serum triglyceride in those weighing about 179 g and 463 g. Therefore, in the following experiments, rats of the Donryu strain weighing about 120 —160 g were used.The hypercholesterolemia induced on feeding a fructose diet to the Donryu rats was prevented by the addition of corn oil, konjac mannan, pectin, guar gum, cholestyramine and clofibrate. Both cholestyramine and phthalate were effective, respectively, in preventing the increase in serum triglyceride.Fructose c...