Effects of Dietary Fibres on Acute Indomethacin-Induced Intestinal Hyperpermeability in the Elderly: A Randomised Placebo Controlled Parallel Clinical Trial.

John-Peter Ganda Mall,Frida Fart,Julia A Sabet,Finn Terje Hegge,Ida Schoultz,Carl Mårten Lindqvist,Robert J Brummer,Ragnhild Nestestog,Åsa V Keita

doi:10.3390/nu12071954

John-Peter Ganda Mall, Frida Fart + Show 7 more

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https://doi.org/10.3390/nu12071954

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Abstract

The effect of dietary fibres on intestinal barrier function has not been well studied, especially in the elderly. We aimed to investigate the potential of the dietary fibres oat β-glucan and wheat arabinoxylan to strengthen the intestinal barrier function and counteract acute non-steroid anti-inflammatory drug (indomethacin)-induced hyperpermeability in the elderly. A general population of elderly subjects (≥65 years, n = 49) was randomised to a daily supplementation (12g/day) of oat β-glucan, arabinoxylan or placebo (maltodextrin) for six weeks. The primary outcome was change in acute indomethacin-induced intestinal permeability from baseline, assessed by an in vivo multi-sugar permeability test. Secondary outcomes were changes from baseline in: gut microbiota composition, systemic inflammatory status and self-reported health. Despite a majority of the study population (85%) showing a habitual fibre intake below the recommendation, no significant effects on acute indomethacin-induced intestinal hyperpermeability in vivo or gut microbiota composition were observed after six weeks intervention with either dietary fibre, compared to placebo.

Highlights

During the last decades lifespan has increased dramatically due to improved health and health-care.The global ageing phenomenon will have a major impact on health-care systems due to an increased prevalence of age-related diseases [1]
The baseline characteristics did not differ significantly between the three intervention groups except for the medical category ‘others’, which contains several subcategories of diverse conditions. These types of conditions were present among 50% of the study participants in the placebo arm and among 15% in the two other arms (Table 2)
The present study focused primarily on the effects of dietary fibres on intestinal barrier function in elderly individuals, with the specific aim to investigate if daily supplementation with arabinoxylan or oat β-glucan could strengthen the intestinal barrier against acute non-steroid anti-inflammatory drugs (NSAIDs)-induced intestinal hyperpermeability compared to placebo

Summary

Introduction

During the last decades lifespan has increased dramatically due to improved health and health-care. The global ageing phenomenon will have a major impact on health-care systems due to an increased prevalence of age-related diseases [1]. According to the National Board of Health and Welfare, gastrointestinal (GI) disorders are one of the most common side-effects that lead to hospitalizations of elderly persons in Sweden, often due to medications, such as non-steroid anti-inflammatory drugs (NSAIDs), commonly used for pain management [2]. The intestinal barrier has the function to absorb nutrients from the gut lumen while simultaneously acting as a barrier towards foreign substances, such as bacterial components and food derived toxicants. NSAIDs are known to induce an increased intestinal permeability across the epithelium [3]. Therapeutic strategies able to increase the Nutrients 2020, 12, 1954; doi:10.3390/nu12071954 www.mdpi.com/journal/nutrients

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