Abstract
To evaluate the effects of dietary fiber from corn husks on hyperlipidemia, the hyperlipidemia model of mice was induced by trans-fatty acids diet,and the mice were randomly divided into the blank control group, the high fat control group(TFA group) and the low, middle and high dose group (2.5,5.0,10.0 G / kg) of dietary fiber from corn husks. Except the blank control group, the mice were fed with high fat diet. The body mass, serum total cholesterol, triglyceride, low density lipoprotein(LDL) and high density lipoprotein(HDL) were measured. The intake of trans-fatty acids resulted in a significant increase in the body weight, serum total cholesterol, triglyceride and LDL(P<0.01), HDL level was significantly lower(P<0.01). Corn husks dietary fiber intervention can reduce the body weight of mice, the serum total cholesterol, triglyceride, LDL concentration and increase HDL concentration. The difference between the high-dose group and the TFA group was significant(P<0.01), and the intervention effect was best in the group with high dose of corn husks dietary fiber. Corn husks dietary fiber can effectively reduce blood lipid in hyperlipidemia mode mice.
Highlights
Hyperlipidemia, known as dyslipidemia or lipid metabolic disorder, refers to high serum cholesterol, triglyceride, Low-density Lipoprotein(LDL) and low high-density Lipoprotein(HDL)
The hyperlipidemia model mice were established, and the corn husks was used as the raw material to prepare the dietary fiber, and the hyperlipidemia model mice were given low, middle and high doses dietary fiber diet, serum TC, TG, HDL-C and low-density lipoprotein cholesterol (LDL-C) were measured by enzyme-linked immunosorbent Assay (Elisa) to study the effect of dietary fiber from corn husks on the level of blood lipid in hyperlipidemia mice induced by trans-fatty acids
During the feeding of corn husks dietary fiber, mice in the middle and high dose groups of corn husks dietary fiber gradually returned to normal behavior
Summary
Experimental animals: 40 healthy and clean SPF KM mice, male or female, weighing (20± 2)g were provided by Changsha Tianqin Biotechnology company. All mice were raised in the standardized laboratory of Changsha Medical University. Mice were allowed to eat and drink freely before the experiment and acclimatize to the environment for at least a week before the experiment. Experimental supplies: HDL Kit, LDL Kit, Total cholesterol Kit, triglyceride kit were provided by Nanjing JianCheng Institute of Biological Engineering. Water soluble corn husks dietary fiber (SDF) made in laboratory
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