Abstract
Summary: Hypercholesterolaemia is considered to be an exacerbating factor in glomerular diseases. This study was designed to assess the effects of dietary cholesterol on the fatty acid composition of glomerular phospholipids and, in particular, on the level of arachidonic acid, since eicosanoids play an important role in the control of glomerular function. High dietary levels of cholesterol for a 3‐week period induced a high level of cholesterol in liver microsomes and hypercholesterolaemia in rats. the level of arachidonic acid in liver microsomes and serum decreased by 32 and 39%, respectively, when compared to controls. the cholesterol content of glomeruli was unchanged by the high cholesterol diet. However, the level of arachidonic acid in glomerular total phospholipids was significantly reduced (by 93%) in cholesterol‐fed rats. the decrease in arachidonic acid content was more marked (20%) in the phosphatidylcholine fraction of glomeruli. the level of linoleic acid increased in total phospholipids and phosphatidylcholine fraction of glomeruli by 15 and 12%, respectively. These results indicate that dietary cholesterol alters the fatty acid composition of glomerular phospholipids, which might contribute to the progression of glomerular diseases.
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