Abstract
Higher serum levels of lycopene are inversely associated with prostate cancer incidence, while alterations in the gonadal hormones testosterone (T) and estradiol (E) modulate risk. Nine‐ to twelve‐week‐old male WT, CMO‐I KO and CMO‐II KO mice were fed either a control, lycopene beadlet‐ (LYC) or tomato powder‐supplemented (TP) diet for four days. Previously we reported that diet and genotype significantly interact, resulting in reduced testicular and total serum T in CMO‐I KO mice fed either TP or LYC, compared to WT mice. We hypothesized that CMO‐I KO genotype, but not CMO‐II KO genotype, would interact with LYC and/or TP to result in decreased serum E and alter testicular mRNA expression of 17β‐hydroxysteroid dehydrogenases (17β‐HSD) 2 & 3. Compared to WT, CMO‐I KO genotype significantly reduced the testicular mRNA expression of both 17β‐HSDs 2 and 3 (p<0.05). Serum E was unchanged, although there were trends towards significant genotype‐diet interactions in the CMO‐I KO/TP (increased; p=0.06) and CMO‐I KO/LYC (decreased; p=0.08) groups, respectively, compared to WT. No changes in serum E were seen in any CMO‐II KO mice. Further work is underway to expand upon these findings.Grant Funding Source : NIH grant PHS‐1‐RO1 CA125384.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.