Abstract
ABSTRACT Trans isomers of polyunsaturated fatty acids (PUFA) are formed during heat treatment of oils. In the present work, the effect of dietary geometrical isomers of α‐linolenic acid (18:3 n‐3) on the Δ6 desaturation of all cis 18:3 n‐3 was investigated, using rat liver microsomes. The desaturation rates were higher in microsomes from animals fed a cis n‐3 deficient diet, as compared to those from the control group or those from rats fed 18:3 n‐3 and its trans isomers. These data and the incorporation of long chain trans PUFA in microsomal lipids suggest that geometrical isomers of 18:3 n‐3 are probably slowly desaturated and elongated into long chain trans polyunsaturated fatty acids compared to 18:3 n‐3.
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