Abstract
Loss of muscle mass and strength (sarcopenia) is a phenomenon that occurs in the elderly. Many studies have found that sarcopenia is related to the decreased function of mitochondria. Additionaly mitochondrial function is known affected by metabolic characteristics of animals. The purpose of this study was to examine the effects of diet on muscle strength, mitochondrial function and metabolic parameters in old rats. Sixteen month‐old rats were randomized into ad libitum (AL), calorie restriction (CR) or high fat diet (HFD) groups and received 14‐weeks of diet intervention. Grip strength, glucose tolerance, and the levels of insulin, free fatty acid (FFA) and triglyceride (TG) were determined by the end of intervention. Soleus muscles were used for the mitochondrial function assay. Our results showed that rats with CR had better normalized grip strength compared with rats with AL and HFD. Accordingly, rats with CR had better mitochondrial function and metabolic characteristics than rats with AL and HFD. Rats with CR had better glucose tolerance than the HFD group, which showed insulin resistance after the intervention. Besides, CR group had lower FFA compared with AL and HFD groups, and lower TG compared with the HFD group. In summary, CR is beneficial to muscle strength, mitochondrial function and metabolic parameters in old rats.
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