Effects of dichlorvos on lipid peroxidation in mice on subacute and subchronic periods

Abstract

In this study, the effects of dichlorvos to lipid peroxidation were investigated at subacute and subchronic periods. Dichlorvos was given with drinking water to Swiss Albino male mice in three dosage levels as 10, 20, and 40 mg/kg b.w. Lipid peroxidation was evaluated by determining the malondialdehyde (MDA) levels in plasma, determining the superoxide dismutase and catalase activities in erythrocytes. The analysis of these enzymes was done in blood samples collected from mice on the days 15 and 45. The results showed that MDA levels increased in dichlorvos treated groups. Actually MDA levels in control and dichlorvos treated groups were determined (as nmol/ml) 10.49, 13.83, 14.30, and 14.50, respectively, at subacute period; 7.77, 8.15, 10.88, and 12.33, respectively, at subchronic period. Catalase activity in erythrocytes decreased at subacute and subchronic periods in dichlorvos treated groups. At subacute period CAT activities were determined (as k/mg Hb) in control and dichlorvos treated groups, 563.45, 532.11, 524.76, and 497.08, respectively; 660.53, 588.84, 525.85, and 512.01, respectively, at subchronic period. When subacute and subchronic periods were compared with each other; it was shown that SOD and CAT activities increased at subchronic period.