Abstract
Replication of adenovirus type 2 (Ad2) was inhibited by dibutyryl-cAMP (db-cAMP) in three fibroblastic cell lines, BHK21, HEK, and WI-38, and in Ad12 transformed BHK21 cells with high intracellular level of cAMP. Yield of Ad12 in WI-38 cells was also reduced. The inhibitory effects were undiminished when db-cAMP was added up to 9 h.p.i. but decreased on later additions. In contrast, replication of either Ad2 or Ad12 was not affected by db-cAMP in two tumor-derived human cell lines, HeLa and KB.
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