Abstract
Phthalic acid esters (PAEs) are extensively used as lasticizers in the manufacture of plastics. In recent studies, PAEs have been detected in air samples, in river water, in tissue of samples of marine animals and in a variety of foods. Several PAEs have been shown to cause testicular atrophy in which the testicular concentration of zinc decreased. The effect of di-2-ethylhexyl phthalate (DEHP), one of the most widely used plasticizers, on lipid composition of the liver, testes and serum in rats were studied in this report. The rats were fed a diet containing 2% of DEHP for 9 days. Non-esteri-fied fatty acid (NEFA), triglyceride (TG), free and total cholesterol, and phospholipid concentration in serum, liver and testis were measured. Furthermore, the fatty acid composition of TG and phospholipid were analysed by gas-liquid chromatography after methylation. Changes in lipid composition and fatty acid composition induced by DEHP administration resembled those due to zinc deficiency. These results suggest that testicular atrophy induced by DEHP administration were due to the promotion of zinc excretion caused by DEHP.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
