Abstract
Objectives To explore the effects of DHT on the mitochondrial respiratory chain enzyme in prostate cancer cells LNCaP, and to investigate its mechanisms. Methods Drogen-dependent(LNCaP)prostate cancer cell lines was obtained by cell culture. The androgen receptor agonist DHT roles in the culture prostate cancer cell line of androgen at different concentrations drugs and mitochondria at different time points of LNCaP under the interventions were extracted, and mitochondrial respiratory changes and differences at different time points and under the action of different drug concentration in LNCaP were measured and compared. Results After DHT acts on LNCaP cells, the content of mitochondrial protein increased significantly(P﹤0.05), but the content of SDH、NADH、COX decreased significantly(P﹤0.05). The difference of the decreasing degree of each index in different time points has different. Conclusions DHT can increase expression of mitochondrial protein in LNCaP, and promote cell proliferation. Key words: Prostatic Neoplasms; Testosterone; Mitochondria
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