Effects of dextrans, heparin and hyperbaric oxygen on mandibular tissue damage after osteotomy in an experimental system

Abstract

The effect of heparin, dextran 40, dextran 70 and hyperbaric oxygen (HBO) therapy to reduce tissue damage after mandibular osteotomy was tested in an experimental system. Tissue damage was recorded morphologically and blood flow and vascular bed was determined by isotope techniques. Subcutaneously administered heparin reduced morphologically determined tissue damage in the incisor odontoblastema, pulp and ameloblastema. Furthermore, central and peripheral bone damage was prevented by heparin. Dextrans had no preventive effect on tissue damage. HBO treatment reduced tissue damage in a similar manner to heparin but also induced reparative events as osteodentin formation in pulps and chondroid reactions in bone. Effects on blood flow and vascular bed provided a basis for a possible role for HBO and heparin treatment in tissue damage after osteotomy.