Effects of Dexmedetomidine on Oxidative Stress, Inflammatory Response, Coagulation Function and Hemodynamics in Patients Undergoing Hysterectomy

Abstract

<i>Objective</i> To investigate the effects of dexmedetomidine on oxidative stress, inflammatory response, coagulation function and hemodynamics in patients undergoing hysterectomy. <i>Methods</i> 92 patients who underwent hysterectomy in our hospital from January to September 2023 were selected as subjects. According to the difference in anesthesia, 46 patients were in the control group and 46 in the dexmedetomidine group. Patients in the control group received midazolam anesthesia, and patients in the dexmedetomidine group received dexmedetomidine anesthesia. The changes of oxidative stress, inflammatory response, coagulation function and hemodynamics were compared between T0 (before anesthesia), T1 (10 min after anesthesia), T2 (after extubation) and T3 (24 h after surgery). <i>Results</i> At T0, there was no significant difference in T-AOC, GSH-Px, MBP, MCP-1, AT III, FDP, MAP and SpO<sub>2</sub> between the two groups (<I>P</I>>0.05). At the time of T1, T2 and T3, the two groups of patients T-AOC, GSH-Px were all lower than T0 (<I>P</I><0.05), MBP and MCP-1 were all higher than T0 (<I>P</I><0.05). The levels of T-AOC and GSH-Px in the dexmedetomidine group were significantly higher than those in the control group (<I>P</I><0.05). The levels of MCP-1 was significantly lower than that of the control group (<I>P</I><0.05). At the T1 and T2, ATIII levels was lower than T0 (<I>P</I><0.05), and FDP levels was higher than T0 (<I>P</I><0.05). At the time of T3, the levels of ATIII and FDP in the dexmedetomidine group recovered to the normal level of T0. There was no significant change in MAP and SpO<sub>2</sub> at each time in the dexmedetomidine group (<I>P</I>>0.05). <i>Conclusion</i> Dexmedetomidine can more effectively alleviate the oxidative stress response in patients with hysterectomy, reduce the symptoms of inflammation in patients, improve the coagulation status of patients and have less influence on hemodynamics, and have high clinical value.