Effects of dexmedetomidine on interleukin-6 and tumor necrosis factor-α level in the patients undergoing one lung ventilation

Abstract

Objective To investigate the effects of dexmedetomidine (Dex) on interleukin-6(IL-6),tumor necrosis factor-α (TNF-α) level and hemodynamics in the patients undergoing one lung ventilation (OLV).Method 40 Patients undergoing one lung ventilation were classified as grade Ⅰ or Ⅱ according to the American Society of Anesthesiologists grading system.The patients were randomly dividede into two groups of dexmedetomidine (group D) or control group (group C).Electrocardiogram (ECG),heart rate (HR),mean arterial pressure (MAP) and saturation of pulse oxygen (SPO2) were monitored during anecthesia.In group D,dexmedetomidine was loaded(0.6 μg/kg) 15 min before anesthesia induction and was infused(0.4 μg/kg/h) during surgery.Group C received saline.In both groups,anesthesia was maintained with sevoflune and sufentanil.ECG,HR and MAP were record before infusion of dexmedetomidine or saline(T1),after the infusion of dexmedetomidine or saline (T2),after the induction of anesthesia (T3),at the beginning of operation (T4),during OLV (T5),and at the discontinuance of intravenous anesthetics(T6).Samples of peripheral blood were taken before infusion of dexmedetomidine or saline(T1),OLV(T5),at the discontinuance of intravenous anesthetics (T6),and 2 hour after the operation (T7).TNF-α and IL-6 were analyzed in the blood samples.Result The age and weight of patients in group C are (54.2 ± 7.1) years old and (65.3 ± 9.0) kg,in group D are (53.7 ±6.9) years old and(63.3 ± 10.1) kg,there is no statistical difference between two groups(P ＞0.05).the concentration of IL-6 and TNF-α increased successively at all the time points in two groups(P ＜ 0.05).The concentration of TNF-α and IL-6 in group D were lower than that in group C at T6,T7 time points during the experimental period (P ＜ 0.05).The HR and MAP values in group D at T2,T3 and T4 time points were lower than that at T1 time point(P ＜0.05),but the HR and MAP values in group C at T2 and T3 time point were significantly higher than that at T1 time point (P ＜ 0.05).Conclusion Dexmedetomidine can inhibit inflammatory response of the patients undergoing OLV. Key words: One lung ventilation; Dexmedetomidine; Inflammatory response markers; Interleukin-6; Tumor necrosis factor-α