Effects of Dexmedetomidine hydrochloride combined with Butorphanol tartrate on stress state in elderly patients with severe illness

Abstract

Objective To investigate the effect of Dexmedetomidine hydrochloride combined with Butorphanol tartrate on stress state in elderly patients with severe illness. Methods A total of 120 elderly patients with severe illness admitted into our hospital from March 2016 to March 2018 were randomized into group A, B and C(n=40, each). Group A was given intravenous Midazolam for analgesia, group B was treated with intravenous Medetomidine for analgesia, and group C received Dexmedetomidine combined with Butorphanol tartrate for analgesia.The differences in mean artery pressure(MAP), heart rate(HR), C-reaction protein(CRP), interleukin-6(IL-6), visual analogue scale(VAS)score and Ramsay score were compared among the three groups. Results The levels of MAP, HR, CRP, IL-6 and VAS score after 24, 48 and 72 hours of combined treatment of dexmedetomidine and butorphanol tartrate were lower in group C than in group B(P 0.05). Ramsay score was higher in group C(intravenous both Dexmedetomidine and Butorphanol tartrate)than in group B(intravenous Dexmedetomidine alone)at 24, 48 and 72 hours after administration(P 0.05). The incidence of adverse reactions was lower in group C than in group A and B(10.0% vs.35.0% and 32.5%, χ2=7.168 and 6.050, P=0.007 and 0.014). There was no significant difference in the incidence of adverse reactions between group A and B(χ2=0.056, P=0.813). Conclusions Dexmedetomidine hydrochloride combined with Butorphanol tartrate can effectively improve hemodynamics, and alleviate inflammatory reaction and pain in elderly patients with severe illness, with a good security.And it is worthy of clinical generalization. Key words: Dexmedetomidine; Butorphanol; Intensive care; Stress