Abstract
Objective: To compare effects of desflurane and sevoflurane on cognitive function in elderly patients undergoing general anesthesia. Methods Eighty elderly patients undergoing general anesthesia under open surgery were enrolled in this study, ASA I ~ II, were divided into group A (desflurane group) and group B (sevoflurane group) randomly. Intravenous drugs included midazolam 0.03 mg / kg, sufentanil 0.5ug / kg, propofol 1-2mg / kg, vecuronium 0.1 mg / kg. All patients were treated with desflurane or sevoflurane to maintain anesthesia, with depth 1.2 ~ 1.4MAC. The mini-mental state examination (MMSE) scores were recorded before operation and 1h, 6h, 12h, 24h and 48h after operation. Results The MMSE scores of the two groups had no significant difference before operation but were significantly lower than those before operation (P <0.05). The MMSE scores of patients in group recovered at 12h after operation(P <0.05). Scores of group B returned in 24h after operation. Scores of group A were higher than group B at 1 h, 6 h and 12 h after operation, the difference was statistically significant. Conclusion The recovery time of cognitive function in elderly desflurane anesthesia patients was significantly less than that of sevoflurane.
Highlights
Postoperative cognitive dysfunction(POCD) is common in elderly patients undergoing complex surgery or emergency surgery, can be expressed as abnormal cognitive function, memory impairment or decline, personality and social integration capacity changes
The aim of this study was to compare the effect of maintenance of anesthesia with desflurane or sevoflurane on the recovery of cognitive function in elderly patients, and to provide reference for clinical work
The current studies show that surgery and general anesthesia will affect the cognitive function of elderly patients significantly[6], a small number of patients still exist cognitive dysfunction after a long time
Summary
Eighty elderly patients undergoing general anesthesia under open surgery were enrolled in this study, ASA I ~ II, were divided into group A (desflurane group) and group B (sevoflurane group) randomly. Intravenous drugs included midazolam 0.03 mg / kg, sufentanil 0.5ug / kg, propofol 1-2mg / kg, vecuronium 0.1 mg / kg. All patients were treated with desflurane or sevoflurane to maintain anesthesia, with depth 1.2 ~ 1.4MAC. The mini-mental state examination (MMSE) scores were recorded before operation and 1h, 6h, 12h, 24h and 48h after operation
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