Abstract
IT is ESTABLISHED that some patients with Addison’s disease given large doses of desoxycorticosterone acetate develop cardiac dilatation and signs of circulatory failure (I). Similar doses in normal dogs cause marked polydipsia and polyuria and result inperiodic muscular weakness associated with very low serum potassium levels (2). The present study is concerned with the effects of prolonged administration of this drug in albinorats. In a preliminary experiment the treated rats failed to show effects similar to those seen in the human patient or in the dogs but changes in the weight of the testes and pituitary glands directed attention to the endocrine organs in subsequent groups. Group I. Due to the striking effect of the drug on serum potassium levels of human patients and dogs, the first group of rats was maintained on a low K diet (3) throughout theperiod of observation.
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