Abstract
Several indole derivatives were characterized on their effects on carbohydrate metabolism in the rat and compared in their insulin-like effects on hepatic gluconeogenesis and glucose consumption in muscle with 5- O-methoxyindole-2-carboxylic acid (MICA) and with indole-3-butyric acid. The substances depressed blood glucose in the fasted adrenalectomized rat at an oral dose of 50–250 mg/kg. Glucose consumption in an isolated muscle preparation was altered only a small amount. In some cases glycogen content of muscle was reduced at a millimolar concentration. All compounds revealed strong inhibition of glucose production from pyruvate in isolated liver slices at a concentration of 10 −4 M. By chemical modification of the indole structure strong inhibitors of gluconeogenesis are obtained. It was not possible to find substances which show a high stimulation of glucose uptake and low activity in inhibiting gluconeogenesis.
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