Abstract

Visual retinal prostheses aim to restore vision for blind individuals who suffer from outer retinal degenerative diseases, such as retinitis pigmentosa and age-related macular degeneration. Perception through retinal prostheses is very limited, but it can be improved by applying object isolation. We used an object isolation algorithm based on integral imaging to isolate objects of interest according to their depth from the camera and applied image processing manipulation to the isolated-object images. Subsequently, we applied a spatial prosthetic vision simulation that converted the isolated-object images to phosphene images. We compared the phosphene images for two types of input images, the original image (before applying object isolation), and the isolated-object image to illustrate the effects of object isolation on simulated prosthetic vision without and with multiple spatial variations of phosphenes, such as size and shape variations, spatial shifts, and dropout rate. The results show an improvement in the perceived shape, contrast, and dynamic range (number of gray levels) of objects in the phosphene image.

Highlights

  • Retinitis pigmentosa and geographic atrophy are outer retinal progressive degenerative diseases that cause a loss of photoreceptor cells

  • One approach intended to help with blindness caused by outer retinal diseases is the use of a retinal prosthesis, which produces artificial electrical stimulation of the remaining healthy cells in the other layers of the retina

  • Retinal prostheses aim to restore vision to blind individuals suffering from outer retinal progressive degenerative disorders, such as retinitis pigmentosa and age-related macular degeneration [6,7,8,9,10,11]

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Summary

Introduction

Retinitis pigmentosa and geographic atrophy are outer retinal progressive degenerative diseases that cause a loss of photoreceptor cells. Both diseases currently have no cure [1,2] and together affect almost 0.7% of the global population [3,4]. One approach intended to help with blindness caused by outer retinal diseases is the use of a retinal prosthesis, which produces artificial electrical stimulation of the remaining healthy cells in the other layers of the retina. Retinal prostheses are a type of visual prostheses in which a microelectrode array is placed on the outer surface of the retina (subretinal prostheses), the inner surface of the retina (epiretinal prostheses), or the suprachoroidal layer (suprachoroidal prostheses), and remaining functioning cells of the retina are stimulated. Retinal prostheses aim to restore vision to blind individuals suffering from outer retinal progressive degenerative disorders, such as retinitis pigmentosa and age-related macular degeneration [6,7,8,9,10,11]

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