Effects of depression on C-reactive protein and low-density lipoprotein levels in patients with coronary artery disease

Abstract

Objective To investigate effects of depression on C-reactive protein （ CRP） and low density lipoprotein （ LDL） levels in patients with coronary artery disease .Methods Eighty coronary heart disease patients with and without depression and 20 coronary heart disease-free cases were selected , CRP and LDL levels were measured and compared among three groups .The correlation of depression scores with CRP and LDL were analyzed .Results Depression self rating scale （ SDS） , and Hamilton Depression Scale （ HAMD） scores of patients with coronary heart disease （ CHD）＋depression were 46.22 ±3.90 , and 24.39 ±3.08 ,which were sig-nificantly higher than control group （22.46 ±6.22,10.36 ±4.22） and non-depressed CHD patients （29.36 ±5.34, and 10.30 ± 4.11 ） （ P 〈0.05 ） , respectively .There were no significant difference between control group and non-depressed CHD patients for SDS and HAMD scores （ P 〉0.05 ） .CRP and LDL levels of patients with CHD ＋depression were （ 24.36 ±3.25 ） mg/L, （ 2.85 ± 1.42 ） mmol/L, which were significantly higher than control group and non-depressed CHD patients （ P 〈0.05 ） .CRP and LDL lev-els of non-depressed CHD patients were higher than control group （ P 〈0.05 ） .SDS, and HAMD scores had a positive correlation with CRP, LDL, and heart rate （ P 〈0.05）.Conclusions CHD patients should remain optimistic relaxed state of mind to improve the treatment of coronary heart disease . Key words: Depression; Coronary disease; C-reactive protein/metabolism; Lipoproteins,LDL/blood