Abstract
Polysaccharides (pachyman) extracted from Poria cocos sclerotium were chemically modified by carboxymethylation and the effects on the structural and biological properties of the polysaccharides were investigated as a function of the degree of carboxymethylation. The degree of substitution (DS) of five carboxymethylated pachyman, coded as CMP1/CMP2/CMP3/CMP4/CMP5, was determined to be 0.44–0.88. The structures were confirmed by FT-IR and their weight-average molecular masses (Mw) were obtained by SEC-LLS. Experimental results showed that derivatives were effective in anti-oxidation and bile acid binding in a dose dependent way. Furthermore, their water solubility and biological activities were improved with the increase of DS. Therefore, results proved that the carboxymethylation of pachyman effectively enhanced their potential biological properties.
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